Department of Biochemistry, Faculty of Medicine
Email: sp.medbiochemcu@gmail.com
Postdoctoral fellow Nagoya City University, Japan
Award of Completion: Bioinformatics and Comparative Genome Analysis Course Institut Pasteur, France
Ph.D. (Biomedical science) Chulalongkorn University, Thailand
B.Sc. (Biochemistry) Chulalongkorn University, Thailand
Research Interest
Researches interests focused on virus and host interactions in terms of:
- Viral factors:
- Characterization of viral genome
- Analysis of significant viral mutations responsible for pathogenesis
- Analysis of phylogenetic tree and evolution
- Host factors:
- Identification of single nucleotide polymorphisms (SNPs) within host genes that associated with susceptibility of viral infection or anti-viral treatment
- Host microRNA profiling in response to viral infection or anti-viral treatment
- Analysis of host microRNA targeting and silencing of viral genes
- Identification of effective siRNA targeting and silencing of viral genes
Research Overview
Viruses display remarkable specificity in both the host species and the cell types that they infect. Viral genomes were characterized by high-throughput sequencing. Then viral mutation, phylogenetic tree and evolution were analyzed based on bioinformatics software. Moreover, host factors such as microRNA expression profiles were analyzed based on the next-generation sequencing (NGS) technology. After that candidate microRNAs were further analyzed for target genes by computational prediction and confirmed by in vitro studies. Understanding the interaction between virus and host cells reveal insight into the basic host components that are required for the viral life cycle and host restriction factors that limit the virus.
Representative Publications